The Difference between Clonidine and Guanfacine | ADHD Management – Alpha-2 Agonists as Key Players

Dr Sanil Rege

We delve into the world of Alpha-2 Agonists and explore their crucial role in ADHD management. Specifically, we will compare two popular medications – Clonidine (Catapres) and Guanfacine (Intuniv) – to help you discover their key differences.

Alpha-2 receptors play a pivotal role in our neural circuitry, influencing everything from attention regulation to stress response. We break down the science behind these receptors, dissecting the presynaptic and postsynaptic functions that shape our brain’s activity.

Learn how Clonidine, with its unique alpha-2A, alpha-2B, and alpha-2C agonistic activity, takes centre stage in treating ADHD, insomnia, PTSD, and even pain management.

Discover how this agent strategically targets specific areas, optimizing noradrenaline levels and bringing relief to hyperactivity and sleep disturbances.

Meanwhile, Guanfacine steps in as a selective alpha-2A agonist, perfectly tailored for ADHD treatment. Uncover its specialized role in strengthening neural networks and countering hyperarousal symptoms. Plus, we’ll unravel the mystery of its minimal hypotensive effects and why it’s a go-to option for certain cases.

Understanding these mechanisms is essential in comprehending how these Alpha-2 Agonists effectively manage ADHD symptoms.

But that’s not all! We will also address a common concern – sleep disturbances. Many individuals with ADHD struggle with sleep issues, and we will discuss how these medications can impact sleep patterns.

Please remember that this video does not replace professional medical advice. Always consult with a healthcare professional for accurate information.

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